KMID : 0811820080120010023
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Journal of Korean Society of Pediatric Nephrology 2008 Volume.12 No. 1 p.23 ~ p.29
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Allograft Immune Reaction of Kidney Transplantation Part 1. Mechanism of Allograft Rejection
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Kang Hee-Gyung
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Abstract
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Kidney allograft transplantation is the most effective method of renal replacement for end stage renal disease patients. Still, it is another kind of ¡¯disease¡¯, requiring immunosuppression to keep the allograft from rejection(allograft immune reaction). Immune system of the allograft recipient recognizes the graft as a ¡¯pathogen (foreign or danger)¡¯, and the allograft-recognizing commanderin-chief of adaptive immune system, T cell, recruits all the components of immune system for attacking the graft. Proper activation and proliferation of T cell require signals from recognizing proper epitope(processed antigen by antigen presenting cell) via T cell receptor, costimulatory stimuli, and cytokines(IL-2). Thus, most of the immunosuppressive agents suppress the process of T cell activation and proliferation.
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KEYWORD
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Allograft immunity, Immune reaction, Renal allograft, Allograft tolerance
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